diff --git a/plugins/obs-ffmpeg/data/locale/en-US.ini b/plugins/obs-ffmpeg/data/locale/en-US.ini
index 9652be160..e8b73293c 100644
--- a/plugins/obs-ffmpeg/data/locale/en-US.ini
+++ b/plugins/obs-ffmpeg/data/locale/en-US.ini
@@ -40,6 +40,7 @@ NVENC.8bitUnsupportedHdr="OBS does not support 8-bit output of Rec. 2100."
 NVENC.I010Unsupported="NVENC does not support I010. Use P010 instead."
 NVENC.10bitUnsupported="Cannot perform 10-bit encode on this encoder."
 NVENC.16bitUnsupported="Cannot perform 16-bit encode on this encoder."
+NVENC.444Unsupported="Cannot perform 4:4:4 encode on this encoder."
 NVENC.NoAV1FallbackPossible="AV1 encoding is not available with the current settings. Try disabling any re-scaling or GPU options that may be set. Check the log for more details."
 NVENC.Preset2.p1="P1: Fastest (Lowest Quality)"
 NVENC.Preset2.p2="P2: Faster (Lower Quality)"
diff --git a/plugins/obs-ffmpeg/obs-nvenc.c b/plugins/obs-ffmpeg/obs-nvenc.c
index 62e5a4ca2..54436daee 100644
--- a/plugins/obs-ffmpeg/obs-nvenc.c
+++ b/plugins/obs-ffmpeg/obs-nvenc.c
@@ -1371,12 +1371,19 @@ static bool init_encoder(struct nvenc_data *enc, enum codec_type codec,
 	int bf = (int)obs_data_get_int(settings, "bf");
 	const bool support_10bit =
 		nv_get_cap(enc, NV_ENC_CAPS_SUPPORT_10BIT_ENCODE);
+	const bool support_444 =
+		nv_get_cap(enc, NV_ENC_CAPS_SUPPORT_YUV444_ENCODE);
 	const int bf_max = nv_get_cap(enc, NV_ENC_CAPS_NUM_MAX_BFRAMES);
 
 	video_t *video = obs_encoder_video(enc->encoder);
 	const struct video_output_info *voi = video_output_get_info(video);
 	enc->in_format = get_preferred_format(voi->format);
 
+	if (enc->in_format == VIDEO_FORMAT_I444 && !support_444) {
+		NV_FAIL(obs_module_text("NVENC.444Unsupported"));
+		return false;
+	}
+
 	if (is_10_bit(enc) && !support_10bit) {
 		NV_FAIL(obs_module_text("NVENC.10bitUnsupported"));
 		return false;