diff --git a/.changeset/tough-jars-study.md b/.changeset/tough-jars-study.md
new file mode 100644
index 0000000000..3bdb07658a
--- /dev/null
+++ b/.changeset/tough-jars-study.md
@@ -0,0 +1,17 @@
+---
+"@pnpm/hooks.read-package-hook": minor
+"pnpm": minor
+---
+
+Added the ability for `overrides` to remove dependencies by specifying `"-"` as the field value [#8572](https://github.com/pnpm/pnpm/issues/8572). For example, to remove `lodash` from the dependencies, use this configuration in `package.json`:
+
+```json
+{
+  "pnpm": {
+    "overrides": {
+      "lodash": "-"
+    }
+  }
+}
+```
+
diff --git a/hooks/read-package-hook/src/createVersionsOverrider.ts b/hooks/read-package-hook/src/createVersionsOverrider.ts
index abfc6cae75..789e86ab6b 100644
--- a/hooks/read-package-hook/src/createVersionsOverrider.ts
+++ b/hooks/read-package-hook/src/createVersionsOverrider.ts
@@ -97,6 +97,11 @@ function overrideDeps (
     )
     if (!versionOverride) continue
 
+    if (versionOverride.newPref === '-') {
+      delete deps[versionOverride.targetPkg.name]
+      continue
+    }
+
     if (versionOverride.localTarget) {
       deps[versionOverride.targetPkg.name] = `${versionOverride.localTarget.protocol}${resolveLocalOverride(versionOverride.localTarget, dir)}`
       continue
diff --git a/hooks/read-package-hook/test/createVersionOverrider.test.ts b/hooks/read-package-hook/test/createVersionOverrider.test.ts
index 88dcc4ea59..e25002c692 100644
--- a/hooks/read-package-hook/test/createVersionOverrider.test.ts
+++ b/hooks/read-package-hook/test/createVersionOverrider.test.ts
@@ -1,5 +1,5 @@
 import path from 'path'
-import { createVersionsOverrider } from '../lib/createVersionsOverrider'
+import { createVersionsOverrider } from '../src/createVersionsOverrider'
 
 test('createVersionsOverrider() matches sub-ranges', () => {
   const overrider = createVersionsOverrider([
@@ -615,3 +615,77 @@ test('createVersionsOverrider() overrides peerDependencies of another dependency
     },
   })
 })
+
+test('createVersionOverrider() removes dependencies', () => {
+  const overrider = createVersionsOverrider([
+    {
+      targetPkg: {
+        name: 'foo',
+      },
+      newPref: '-',
+    },
+    {
+      parentPkg: {
+        name: 'bar',
+      },
+      targetPkg: {
+        name: 'baz',
+      },
+      newPref: '-',
+    },
+    {
+      targetPkg: {
+        name: 'qux',
+        pref: '2',
+      },
+      newPref: '-',
+    },
+  ], process.cwd())
+  expect(
+    overrider({
+      dependencies: {
+        foo: '0.1.2',
+        bar: '1.2.3',
+        baz: '1.0.0',
+        qux: '2.1.0',
+      },
+    })
+  ).toStrictEqual({
+    dependencies: {
+      bar: '1.2.3',
+      baz: '1.0.0',
+    },
+  })
+  expect(
+    overrider({
+      name: 'bar',
+      dependencies: {
+        foo: '0.1.2',
+        bar: '1.2.3',
+        baz: '1.0.0',
+        qux: '2.1.0',
+      },
+    })
+  ).toStrictEqual({
+    name: expect.anything(),
+    dependencies: {
+      bar: '1.2.3',
+    },
+  })
+  expect(
+    overrider({
+      dependencies: {
+        foo: '0.1.2',
+        bar: '1.2.3',
+        baz: '1.0.0',
+        qux: '3.2.1',
+      },
+    })
+  ).toStrictEqual({
+    dependencies: {
+      bar: '1.2.3',
+      baz: '1.0.0',
+      qux: '3.2.1',
+    },
+  })
+})
diff --git a/pkg-manager/core/test/install/overrides.ts b/pkg-manager/core/test/install/overrides.ts
index 8746508c39..dea4c41c05 100644
--- a/pkg-manager/core/test/install/overrides.ts
+++ b/pkg-manager/core/test/install/overrides.ts
@@ -2,15 +2,13 @@ import path from 'path'
 import fs from 'fs'
 import { sync as readYamlFile } from 'read-yaml-file'
 import { PnpmError } from '@pnpm/error'
-import { prepareEmpty, preparePackages } from '@pnpm/prepare'
+import { prepare, prepareEmpty, preparePackages } from '@pnpm/prepare'
 import { addDistTag } from '@pnpm/registry-mock'
 import { WANTED_LOCKFILE } from '@pnpm/constants'
 import { type MutatedProject, type ProjectOptions, addDependenciesToPackage, mutateModulesInSingleProject, mutateModules } from '@pnpm/core'
 import { type LockfileFileV9 } from '@pnpm/lockfile.types'
 import { type ProjectRootDir, type ProjectManifest } from '@pnpm/types'
-import {
-  testDefaults,
-} from '../utils'
+import { testDefaults } from '../utils'
 
 test('versions are replaced with versions specified through overrides option', async () => {
   const project = prepareEmpty()
@@ -252,3 +250,47 @@ test('overrides with local file and link specs', async () => {
   expect(fs.realpathSync(path.join(indirectPrefix, '@pnpm.e2e/pkg-c'))).toBe(path.resolve('overrides/pkg'))
   expect(fs.realpathSync(path.join(indirectPrefix, '@pnpm.e2e/pkg-d'))).toBe(path.resolve('overrides/pkg'))
 })
+
+test('overrides remove dependencies', async () => {
+  const manifest: ProjectManifest = {
+    dependencies: {
+      '@pnpm.e2e/pkg-with-good-optional': '1.0.0',
+    },
+    pnpm: {
+      overrides: {
+        '@pnpm.e2e/pkg-with-good-optional>is-positive': '-',
+      },
+    },
+  }
+
+  const project = prepare(manifest)
+
+  await mutateModulesInSingleProject({
+    manifest,
+    mutation: 'install',
+    rootDir: process.cwd() as ProjectRootDir,
+  }, testDefaults({
+    overrides: manifest.pnpm?.overrides,
+  }))
+
+  // assert that @pnpm.e2e/pkg-with-good-optional@1.0.0 depends on is-positive@1.0.0
+  expect(project.requireModule('@pnpm.e2e/pkg-with-good-optional/package.json')).toMatchObject({
+    version: '1.0.0',
+    optionalDependencies: {
+      'is-positive': '1.0.0',
+    },
+  })
+
+  // yet because of the overrides, it installs @pnpm.e2e/pkg-with-good-optional@1.0.0 without is-positive@1.0.0
+  const lockfile = project.readLockfile()
+  expect(lockfile.snapshots).toHaveProperty(['@pnpm.e2e/pkg-with-good-optional@1.0.0'])
+  expect(lockfile.snapshots['@pnpm.e2e/pkg-with-good-optional@1.0.0']).not.toHaveProperty(['optionalDependencies', 'is-positive'])
+  expect(lockfile.snapshots).not.toHaveProperty(['is-positive@1.0.0'])
+  expect(lockfile.packages).toHaveProperty(['@pnpm.e2e/pkg-with-good-optional@1.0.0'])
+  expect(lockfile.packages).not.toHaveProperty(['is-positive@1.0.0'])
+  expect(
+    fs.existsSync('node_modules/.pnpm/@pnpm.e2e+pkg-with-good-optional@1.0.0/node_modules/is-positive')
+  ).toBe(false)
+  const currentLockfile = project.readCurrentLockfile()
+  expect(lockfile.overrides).toStrictEqual(currentLockfile.overrides)
+})