diff --git a/.changeset/solid-regions-ring.md b/.changeset/solid-regions-ring.md
new file mode 100644
index 0000000000..6cf4c8b2f0
--- /dev/null
+++ b/.changeset/solid-regions-ring.md
@@ -0,0 +1,6 @@
+---
+"@pnpm/npm-resolver": patch
+"pnpm": patch
+---
+
+Normalize the tarball URLs before saving them to the lockfile. URLs should not contain default ports, like :80 for http and :443 for https [#10273](https://github.com/pnpm/pnpm/pull/10273).
diff --git a/resolving/npm-resolver/src/index.ts b/resolving/npm-resolver/src/index.ts
index d7f9a13515..4aa3a14fd4 100644
--- a/resolving/npm-resolver/src/index.ts
+++ b/resolving/npm-resolver/src/index.ts
@@ -50,6 +50,7 @@ import { workspacePrefToNpm } from './workspacePrefToNpm.js'
 import { whichVersionIsPinned } from './whichVersionIsPinned.js'
 import { pickVersionByVersionRange } from './pickPackageFromMeta.js'
 import { failIfTrustDowngraded } from './trustChecks.js'
+import { normalizeRegistryUrl } from './normalizeRegistryUrl.js'
 
 export interface NoMatchingVersionErrorOptions {
   wantedDependency: WantedDependency
@@ -348,7 +349,7 @@ async function resolveNpm (
   const id = `${pickedPackage.name}@${pickedPackage.version}` as PkgResolutionId
   const resolution = {
     integrity: getIntegrity(pickedPackage.dist),
-    tarball: pickedPackage.dist.tarball,
+    tarball: normalizeRegistryUrl(pickedPackage.dist.tarball),
   }
   let normalizedBareSpecifier: string | undefined
   if (opts.calcSpecifier) {
@@ -400,7 +401,7 @@ async function resolveJsr (
   const id = `${pickedPackage.name}@${pickedPackage.version}` as PkgResolutionId
   const resolution = {
     integrity: getIntegrity(pickedPackage.dist),
-    tarball: pickedPackage.dist.tarball,
+    tarball: normalizeRegistryUrl(pickedPackage.dist.tarball),
   }
   return {
     id,
diff --git a/resolving/npm-resolver/src/normalizeRegistryUrl.ts b/resolving/npm-resolver/src/normalizeRegistryUrl.ts
new file mode 100644
index 0000000000..171b858ab9
--- /dev/null
+++ b/resolving/npm-resolver/src/normalizeRegistryUrl.ts
@@ -0,0 +1,10 @@
+/**
+ * Remove default ports (80 for HTTP, 443 for HTTPS) to ensure consistency
+ */
+export function normalizeRegistryUrl (urlString: string): string {
+  try {
+    return new URL(urlString).toString()
+  } catch {
+    return urlString
+  }
+}
diff --git a/resolving/npm-resolver/test/index.ts b/resolving/npm-resolver/test/index.ts
index 24e3852334..992d738807 100644
--- a/resolving/npm-resolver/test/index.ts
+++ b/resolving/npm-resolver/test/index.ts
@@ -79,6 +79,35 @@ test('resolveFromNpm()', async () => {
   expect(meta['dist-tags']).toBeTruthy()
 })
 
+test('resolveFromNpm() strips port 80 from http tarball URLs', async () => {
+  nock(registries.default)
+    .get('/is-positive')
+    .reply(200, {
+      ...isPositiveMeta,
+      versions: {
+        '1.0.0': {
+          ...isPositiveMeta.versions['1.0.0'],
+          dist: {
+            ...isPositiveMeta.versions['1.0.0'].dist,
+            tarball: 'http://registry.npmjs.org:80/is-positive/-/is-positive-1.0.0.tgz',
+          },
+        },
+      },
+    })
+
+  const cacheDir = temporaryDirectory()
+  const { resolveFromNpm } = createResolveFromNpm({
+    cacheDir,
+    registries,
+  })
+  const resolveResult = await resolveFromNpm({ alias: 'is-positive', bareSpecifier: '1.0.0' }, { calcSpecifier: true })
+
+  expect(resolveResult!.resolution).toStrictEqual({
+    integrity: 'sha512-9cI+DmhNhA8ioT/3EJFnt0s1yehnAECyIOXdT+2uQGzcEEBaj8oNmVWj33+ZjPndMIFRQh8JeJlEu1uv5/J7pQ==',
+    tarball: 'http://registry.npmjs.org/is-positive/-/is-positive-1.0.0.tgz',
+  })
+})
+
 test('resolveFromNpm() does not save mutated meta to the cache', async () => {
   nock(registries.default)
     .get('/is-positive')
diff --git a/resolving/npm-resolver/test/normalizeRegistryUrl.test.ts b/resolving/npm-resolver/test/normalizeRegistryUrl.test.ts
new file mode 100644
index 0000000000..5ad05234ae
--- /dev/null
+++ b/resolving/npm-resolver/test/normalizeRegistryUrl.test.ts
@@ -0,0 +1,14 @@
+import { normalizeRegistryUrl } from '../lib/normalizeRegistryUrl.js'
+
+test.each([
+  ['https://registry.example.com:443/package.tgz', 'https://registry.example.com/package.tgz'],
+  ['http://registry.example.com:80/package.tgz', 'http://registry.example.com/package.tgz'],
+  ['https://registry.example.com:8443/package.tgz', 'https://registry.example.com:8443/package.tgz'],
+  ['http://registry.example.com:8080/package.tgz', 'http://registry.example.com:8080/package.tgz'],
+  ['https://registry.example.com/package.tgz', 'https://registry.example.com/package.tgz'],
+  ['http://registry.example.com/package.tgz', 'http://registry.example.com/package.tgz'],
+  ['https://artifactory:443/api/npm/npm-virtual/uuid/-/uuid-9.0.1.tgz', 'https://artifactory/api/npm/npm-virtual/uuid/-/uuid-9.0.1.tgz'],
+  ['invalid-url', 'invalid-url'],
+])('normalizeRegistryUrl(%s) should return %s', (input, expected) => {
+  expect(normalizeRegistryUrl(input)).toBe(expected)
+})