diff --git a/.changeset/curvy-feet-applaud.md b/.changeset/curvy-feet-applaud.md
new file mode 100644
index 0000000000..3f1b3f5b9d
--- /dev/null
+++ b/.changeset/curvy-feet-applaud.md
@@ -0,0 +1,5 @@
+---
+"@pnpm/fetch": patch
+---
+
+Some HTTP errors should not be retried [#4917](https://github.com/pnpm/pnpm/pull/4917).
diff --git a/packages/fetch/src/fetch.ts b/packages/fetch/src/fetch.ts
index 76628db2b4..f201c277e5 100644
--- a/packages/fetch/src/fetch.ts
+++ b/packages/fetch/src/fetch.ts
@@ -10,6 +10,11 @@ interface URLLike {
   href: string
 }
 
+const NO_RETRY_ERROR_CODES = new Set([
+  'SELF_SIGNED_CERT_IN_CHAIN',
+  'ERR_OSSL_PEM_NO_START_LINE',
+])
+
 export type RequestInfo = string | URLLike | Request
 
 export interface RequestInit extends NodeRequestInit {
@@ -42,6 +47,9 @@ export default async function fetchRetry (url: RequestInfo, opts: RequestInit =
           return
         }
       } catch (error: any) { // eslint-disable-line
+        if (error.code && NO_RETRY_ERROR_CODES.has(error.code)) {
+          throw error
+        }
         const timeout = op.retry(error)
         if (timeout === false) {
           reject(op.mainError())