diff --git a/docs/source/markdown/podman-kube-play.1.md.in b/docs/source/markdown/podman-kube-play.1.md.in
index 18dd1e5650..0f100be435 100644
--- a/docs/source/markdown/podman-kube-play.1.md.in
+++ b/docs/source/markdown/podman-kube-play.1.md.in
@@ -57,6 +57,10 @@ Note: To customize the name of the infra container created during `podman kube p
 
 Note: Use the **io.podman.annotations.pids-limit/$ctrname** annotation to configure the pod's pids limit.
 
+Note: Use the **io.podman.annotations.cpuset/$ctrname** annotation to restrict a container's execution to a specific set of CPU cores. This is equivalent to the `--cpuset-cpus=number` option in podman-run(1).
+
+Note: Use the **io.podman.annotations.memory-nodes/$ctrname** annotation to restrict a container's memory allocations to a specific set of memory nodes on NUMA systems. This is equivalent to the `--cpuset-mems=nodes` option in podman-run(1).
+
 `Kubernetes PersistentVolumeClaims`
 
 A Kubernetes PersistentVolumeClaim represents a Podman named volume. Only the PersistentVolumeClaim name is required by Podman to create a volume. Kubernetes annotations can be used to make use of the available options for Podman volumes.
diff --git a/libpod/define/annotations.go b/libpod/define/annotations.go
index e2e562902c..b743c60523 100644
--- a/libpod/define/annotations.go
+++ b/libpod/define/annotations.go
@@ -172,6 +172,12 @@ const (
 	// PIDsLimitAnnotation is used to limit the number of PIDs
 	PIDsLimitAnnotation = "io.podman.annotations.pids-limit"
 
+	// CpusetAnnotation is used to restrict execution to specific CPU cores
+	CpusetAnnotation = "io.podman.annotations.cpuset"
+
+	// MemoryNodesAnnotation is used to restrict memory allocations to specific memory nodes on NUMA systems
+	MemoryNodesAnnotation = "io.podman.annotations.memory-nodes"
+
 	// TotalAnnotationSizeLimitB is the max length of annotations allowed by Kubernetes.
 	TotalAnnotationSizeLimitB int = 256 * (1 << 10) // 256 kB
 )
diff --git a/pkg/specgen/generate/kube/kube.go b/pkg/specgen/generate/kube/kube.go
index d3eb586eb7..86f7694816 100644
--- a/pkg/specgen/generate/kube/kube.go
+++ b/pkg/specgen/generate/kube/kube.go
@@ -393,6 +393,28 @@ func ToSpecGen(ctx context.Context, opts *CtrSpecGenOptions) (*specgen.SpecGener
 		}
 	}
 
+	if cpuset, ok := annotations[define.CpusetAnnotation+"/"+opts.Container.Name]; ok {
+		s.Annotations[define.CpusetAnnotation] = cpuset
+		if s.ResourceLimits == nil {
+			s.ResourceLimits = &spec.LinuxResources{}
+		}
+		if s.ResourceLimits.CPU == nil {
+			s.ResourceLimits.CPU = &spec.LinuxCPU{}
+		}
+		s.ResourceLimits.CPU.Cpus = cpuset
+	}
+
+	if memNodes, ok := annotations[define.MemoryNodesAnnotation+"/"+opts.Container.Name]; ok {
+		s.Annotations[define.MemoryNodesAnnotation] = memNodes
+		if s.ResourceLimits == nil {
+			s.ResourceLimits = &spec.LinuxResources{}
+		}
+		if s.ResourceLimits.CPU == nil {
+			s.ResourceLimits.CPU = &spec.LinuxCPU{}
+		}
+		s.ResourceLimits.CPU.Mems = memNodes
+	}
+
 	if label, ok := opts.Annotations[define.InspectAnnotationLabel+"/"+opts.Container.Name]; ok {
 		if label == "nested" {
 			s.ContainerSecurityConfig.LabelNested = &localTrue
diff --git a/pkg/specgenutil/specgen.go b/pkg/specgenutil/specgen.go
index 5f1e44fc47..33f6b5e6e2 100644
--- a/pkg/specgenutil/specgen.go
+++ b/pkg/specgenutil/specgen.go
@@ -531,6 +531,14 @@ func FillOutSpecGen(s *specgen.SpecGenerator, c *entities.ContainerCreateOptions
 		s.Annotations[define.PIDsLimitAnnotation] = strconv.FormatInt(*c.PIDsLimit, 10)
 	}
 
+	if c.CPUSetCPUs != "" {
+		s.Annotations[define.CpusetAnnotation] = c.CPUSetCPUs
+	}
+
+	if c.CPUSetMems != "" {
+		s.Annotations[define.MemoryNodesAnnotation] = c.CPUSetMems
+	}
+
 	if len(c.StorageOpts) > 0 {
 		opts := make(map[string]string, len(c.StorageOpts))
 		for _, opt := range c.StorageOpts {
diff --git a/test/e2e/play_kube_test.go b/test/e2e/play_kube_test.go
index 6902d51178..b1d93320d3 100644
--- a/test/e2e/play_kube_test.go
+++ b/test/e2e/play_kube_test.go
@@ -6194,4 +6194,31 @@ spec:
 		Expect(exec.OutputToString()).To(Equal("10"))
 	})
 
+	It("test cpuset annotation", func() {
+		ctrAnnotation := "io.podman.annotations.cpuset/" + defaultCtrName
+		pod := getPod(withAnnotation(ctrAnnotation, "0"), withPodInitCtr(getCtr(withImage(CITEST_IMAGE), withCmd([]string{"printenv", "container"}), withInitCtr(), withName("init-test"))), withCtr(getCtr(withImage(CITEST_IMAGE), withCmd([]string{"top"}))))
+		err := generateKubeYaml("pod", pod, kubeYaml)
+		Expect(err).ToNot(HaveOccurred())
+
+		kube := podmanTest.Podman([]string{"kube", "play", kubeYaml})
+		kube.WaitWithDefaultTimeout()
+		Expect(kube).Should(ExitCleanly())
+
+		exec := podmanTest.PodmanExitCleanly("exec", "testPod-"+defaultCtrName, "cat", "/sys/fs/cgroup/cpuset.cpus.effective")
+		Expect(exec.OutputToString()).To(Equal("0"))
+	})
+
+	It("test memory-nodes annotation", func() {
+		ctrAnnotation := "io.podman.annotations.memory-nodes/" + defaultCtrName
+		pod := getPod(withAnnotation(ctrAnnotation, "0"), withPodInitCtr(getCtr(withImage(CITEST_IMAGE), withCmd([]string{"printenv", "container"}), withInitCtr(), withName("init-test"))), withCtr(getCtr(withImage(CITEST_IMAGE), withCmd([]string{"top"}))))
+		err := generateKubeYaml("pod", pod, kubeYaml)
+		Expect(err).ToNot(HaveOccurred())
+
+		kube := podmanTest.Podman([]string{"kube", "play", kubeYaml})
+		kube.WaitWithDefaultTimeout()
+		Expect(kube).Should(ExitCleanly())
+
+		exec := podmanTest.PodmanExitCleanly("exec", "testPod-"+defaultCtrName, "cat", "/sys/fs/cgroup/cpuset.mems.effective")
+		Expect(exec.OutputToString()).To(Equal("0"))
+	})
 })