diff --git a/docs/source/markdown/podman-systemd.unit.5.md b/docs/source/markdown/podman-systemd.unit.5.md
index d959f44d93..e5e0d12c8d 100644
--- a/docs/source/markdown/podman-systemd.unit.5.md
+++ b/docs/source/markdown/podman-systemd.unit.5.md
@@ -283,6 +283,22 @@ container that forwards signals and reaps processes.
 Set the seccomp profile to use in the container. If unset, the default podman profile is used.
 Set to either the pathname of a json file, or `unconfined` to disable the seccomp filters.
 
+#### `SecurityLabelDisable=`
+
+Turn off label separation for the container.
+
+#### `SecurityLabelFileType=`
+
+Set the label file type for the container files.
+
+#### `SecurityLabelLevel=`
+
+Set the label process level for the container processes.
+
+#### `SecurityLabelType=`
+
+Set the label process type for the container processes.
+
 #### `Timezone=` (if unset uses system-configured default)
 
 The timezone to run the container in.
diff --git a/pkg/systemd/quadlet/quadlet.go b/pkg/systemd/quadlet/quadlet.go
index 3c7f6e2e76..2c32e3c13a 100644
--- a/pkg/systemd/quadlet/quadlet.go
+++ b/pkg/systemd/quadlet/quadlet.go
@@ -31,51 +31,55 @@ const (
 
 // All the supported quadlet keys
 const (
-	KeyContainerName     = "ContainerName"
-	KeyImage             = "Image"
-	KeyEnvironment       = "Environment"
-	KeyEnvironmentFile   = "EnvironmentFile"
-	KeyEnvironmentHost   = "EnvironmentHost"
-	KeyExec              = "Exec"
-	KeyNoNewPrivileges   = "NoNewPrivileges"
-	KeyDropCapability    = "DropCapability"
-	KeyAddCapability     = "AddCapability"
-	KeyReadOnly          = "ReadOnly"
-	KeyRemapUsers        = "RemapUsers"
-	KeyRemapUID          = "RemapUid"
-	KeyRemapGID          = "RemapGid"
-	KeyRemapUIDSize      = "RemapUidSize"
-	KeyRootfs            = "Rootfs"
-	KeyNotify            = "Notify"
-	KeyExposeHostPort    = "ExposeHostPort"
-	KeyPublishPort       = "PublishPort"
-	KeyUser              = "User"
-	KeyGroup             = "Group"
-	KeyDevice            = "Device"
-	KeyType              = "Type"
-	KeyOptions           = "Options"
-	KeyCopy              = "Copy"
-	KeyVolume            = "Volume"
-	KeyPodmanArgs        = "PodmanArgs"
-	KeyLabel             = "Label"
-	KeyAnnotation        = "Annotation"
-	KeyRunInit           = "RunInit"
-	KeyVolatileTmp       = "VolatileTmp"
-	KeyTimezone          = "Timezone"
-	KeySeccompProfile    = "SeccompProfile"
-	KeyAddDevice         = "AddDevice"
-	KeyNetwork           = "Network"
-	KeyYaml              = "Yaml"
-	KeyNetworkDisableDNS = "DisableDNS"
-	KeyNetworkDriver     = "Driver"
-	KeyNetworkGateway    = "Gateway"
-	KeyNetworkInternal   = "Internal"
-	KeyNetworkIPRange    = "IPRange"
-	KeyNetworkIPAMDriver = "IPAMDriver"
-	KeyNetworkIPv6       = "IPv6"
-	KeyNetworkOptions    = "Options"
-	KeyNetworkSubnet     = "Subnet"
-	KeyConfigMap         = "ConfigMap"
+	KeyContainerName         = "ContainerName"
+	KeyImage                 = "Image"
+	KeyEnvironment           = "Environment"
+	KeyEnvironmentFile       = "EnvironmentFile"
+	KeyEnvironmentHost       = "EnvironmentHost"
+	KeyExec                  = "Exec"
+	KeyNoNewPrivileges       = "NoNewPrivileges"
+	KeyDropCapability        = "DropCapability"
+	KeyAddCapability         = "AddCapability"
+	KeyReadOnly              = "ReadOnly"
+	KeyRemapUsers            = "RemapUsers"
+	KeyRemapUID              = "RemapUid"
+	KeyRemapGID              = "RemapGid"
+	KeyRemapUIDSize          = "RemapUidSize"
+	KeyRootfs                = "Rootfs"
+	KeyNotify                = "Notify"
+	KeyExposeHostPort        = "ExposeHostPort"
+	KeyPublishPort           = "PublishPort"
+	KeyUser                  = "User"
+	KeyGroup                 = "Group"
+	KeyDevice                = "Device"
+	KeyType                  = "Type"
+	KeyOptions               = "Options"
+	KeyCopy                  = "Copy"
+	KeyVolume                = "Volume"
+	KeyPodmanArgs            = "PodmanArgs"
+	KeyLabel                 = "Label"
+	KeyAnnotation            = "Annotation"
+	KeyRunInit               = "RunInit"
+	KeyVolatileTmp           = "VolatileTmp"
+	KeyTimezone              = "Timezone"
+	KeySeccompProfile        = "SeccompProfile"
+	KeySecurityLabelDisable  = "SecurityLabelDisable"
+	KeySecurityLabelFileType = "SecurityLabelFileType"
+	KeySecurityLabelType     = "SecurityLabelType"
+	KeySecurityLabelLevel    = "SecurityLabelLevel"
+	KeyAddDevice             = "AddDevice"
+	KeyNetwork               = "Network"
+	KeyYaml                  = "Yaml"
+	KeyNetworkDisableDNS     = "DisableDNS"
+	KeyNetworkDriver         = "Driver"
+	KeyNetworkGateway        = "Gateway"
+	KeyNetworkInternal       = "Internal"
+	KeyNetworkIPRange        = "IPRange"
+	KeyNetworkIPAMDriver     = "IPAMDriver"
+	KeyNetworkIPv6           = "IPv6"
+	KeyNetworkOptions        = "Options"
+	KeyNetworkSubnet         = "Subnet"
+	KeyConfigMap             = "ConfigMap"
 )
 
 var (
@@ -83,36 +87,40 @@ var (
 
 	// Supported keys in "Container" group
 	supportedContainerKeys = map[string]bool{
-		KeyContainerName:   true,
-		KeyImage:           true,
-		KeyEnvironment:     true,
-		KeyEnvironmentFile: true,
-		KeyEnvironmentHost: true,
-		KeyExec:            true,
-		KeyNoNewPrivileges: true,
-		KeyDropCapability:  true,
-		KeyAddCapability:   true,
-		KeyReadOnly:        true,
-		KeyRemapUsers:      true,
-		KeyRemapUID:        true,
-		KeyRemapGID:        true,
-		KeyRemapUIDSize:    true,
-		KeyRootfs:          true,
-		KeyNotify:          true,
-		KeyExposeHostPort:  true,
-		KeyPublishPort:     true,
-		KeyUser:            true,
-		KeyGroup:           true,
-		KeyVolume:          true,
-		KeyPodmanArgs:      true,
-		KeyLabel:           true,
-		KeyAnnotation:      true,
-		KeyRunInit:         true,
-		KeyVolatileTmp:     true,
-		KeyTimezone:        true,
-		KeySeccompProfile:  true,
-		KeyAddDevice:       true,
-		KeyNetwork:         true,
+		KeyContainerName:         true,
+		KeyImage:                 true,
+		KeyEnvironment:           true,
+		KeyEnvironmentFile:       true,
+		KeyEnvironmentHost:       true,
+		KeyExec:                  true,
+		KeyNoNewPrivileges:       true,
+		KeyDropCapability:        true,
+		KeyAddCapability:         true,
+		KeyReadOnly:              true,
+		KeyRemapUsers:            true,
+		KeyRemapUID:              true,
+		KeyRemapGID:              true,
+		KeyRemapUIDSize:          true,
+		KeyRootfs:                true,
+		KeyNotify:                true,
+		KeyExposeHostPort:        true,
+		KeyPublishPort:           true,
+		KeyUser:                  true,
+		KeyGroup:                 true,
+		KeyVolume:                true,
+		KeyPodmanArgs:            true,
+		KeyLabel:                 true,
+		KeyAnnotation:            true,
+		KeyRunInit:               true,
+		KeyVolatileTmp:           true,
+		KeyTimezone:              true,
+		KeySeccompProfile:        true,
+		KeySecurityLabelDisable:  true,
+		KeySecurityLabelFileType: true,
+		KeySecurityLabelType:     true,
+		KeySecurityLabelLevel:    true,
+		KeyAddDevice:             true,
+		KeyNetwork:               true,
 	}
 
 	// Supported keys in "Volume" group
@@ -353,6 +361,26 @@ func ConvertContainer(container *parser.UnitFile, isUser bool) (*parser.UnitFile
 		podman.add("--security-opt=no-new-privileges")
 	}
 
+	securityLabelDisable := container.LookupBooleanWithDefault(ContainerGroup, KeySecurityLabelDisable, false)
+	if securityLabelDisable {
+		podman.add("--security-opt", "label:disable")
+	}
+
+	securityLabelType, _ := container.Lookup(ContainerGroup, KeySecurityLabelType)
+	if len(securityLabelType) > 0 {
+		podman.add("--security-opt", fmt.Sprintf("label=type:%s", securityLabelType))
+	}
+
+	securityLabelFileType, _ := container.Lookup(ContainerGroup, KeySecurityLabelFileType)
+	if len(securityLabelFileType) > 0 {
+		podman.add("--security-opt", fmt.Sprintf("label=filetype:%s", securityLabelFileType))
+	}
+
+	securityLabelLevel, _ := container.Lookup(ContainerGroup, KeySecurityLabelLevel)
+	if len(securityLabelLevel) > 0 {
+		podman.add("--security-opt", fmt.Sprintf("label=level:%s", securityLabelLevel))
+	}
+
 	// But allow overrides with AddCapability
 	devices := container.LookupAllStrv(ContainerGroup, KeyAddDevice)
 	for _, device := range devices {
diff --git a/test/e2e/quadlet/disableselinux.container b/test/e2e/quadlet/disableselinux.container
new file mode 100644
index 0000000000..5f3182b5cb
--- /dev/null
+++ b/test/e2e/quadlet/disableselinux.container
@@ -0,0 +1,5 @@
+## assert-podman-args "--security-opt" "label:disable"
+
+[Container]
+Image=localhost/imagename
+SecurityLabelDisable=true
diff --git a/test/e2e/quadlet/selinux.container b/test/e2e/quadlet/selinux.container
new file mode 100644
index 0000000000..c4f6ea02fe
--- /dev/null
+++ b/test/e2e/quadlet/selinux.container
@@ -0,0 +1,9 @@
+## assert-podman-args "--security-opt" "label=type:foobar_t"
+## assert-podman-args "--security-opt" "label=level:s0:c1000,c10001"
+## assert-podman-args "--security-opt" "label=filetype:foobar_file_t"
+
+[Container]
+Image=localhost/imagename
+SecurityLabelType=foobar_t
+SecurityLabelFileType=foobar_file_t
+SecurityLabelLevel=s0:c1000,c10001
diff --git a/test/e2e/quadlet_test.go b/test/e2e/quadlet_test.go
index a778e4ddc8..fd1d621e07 100644
--- a/test/e2e/quadlet_test.go
+++ b/test/e2e/quadlet_test.go
@@ -447,6 +447,7 @@ var _ = Describe("quadlet system generator", func() {
 		Entry("basepodman.container", "basepodman.container"),
 		Entry("capabilities.container", "capabilities.container"),
 		Entry("capabilities2.container", "capabilities2.container"),
+		Entry("disableselinux.container", "disableselinux.container"),
 		Entry("devices.container", "devices.container"),
 		Entry("env.container", "env.container"),
 		Entry("escapes.container", "escapes.container"),
@@ -461,6 +462,7 @@ var _ = Describe("quadlet system generator", func() {
 		Entry("notify.container", "notify.container"),
 		Entry("oneshot.container", "oneshot.container"),
 		Entry("rootfs.container", "rootfs.container"),
+		Entry("selinux.container", "selinux.container"),
 		Entry("other-sections.container", "other-sections.container"),
 		Entry("podmanargs.container", "podmanargs.container"),
 		Entry("ports.container", "ports.container"),
diff --git a/test/system/252-quadlet.bats b/test/system/252-quadlet.bats
index d130ee962f..a83be32df7 100644
--- a/test/system/252-quadlet.bats
+++ b/test/system/252-quadlet.bats
@@ -424,5 +424,57 @@ EOF
     is "$output" '.*STARTED CONTAINER.*'
 }
 
+@test "quadlet - selinux disable" {
+    skip_if_no_selinux
+    local quadlet_file=$PODMAN_TMPDIR/basic_$(random_string).container
+    cat > $quadlet_file <<EOF
+[Container]
+Image=$IMAGE
+SecurityLabelDisable=true
+Exec=sh -c "echo STARTED CONTAINER; echo "READY=1" | socat -u STDIN unix-sendto:\$NOTIFY_SOCKET; top"
+EOF
+
+    run_quadlet "$quadlet_file"
+    service_setup $QUADLET_SERVICE_NAME
+
+    # Ensure we have output. Output is synced via sd-notify (socat in Exec)
+    run journalctl "--since=$STARTED_TIME" --unit="$QUADLET_SERVICE_NAME"
+    is "$output" '.*STARTED CONTAINER.*'
+
+    run_podman container inspect  --format "{{.ProcessLabel}}" $QUADLET_CONTAINER_NAME
+    is "$output" "" "container should be started without specifying a Process Label"
+
+    service_cleanup $QUADLET_SERVICE_NAME failed
+}
+
+@test "quadlet - selinux labels" {
+    skip_if_no_selinux
+    NAME=$(random_string)
+    local quadlet_file=$PODMAN_TMPDIR/basic_$(random_string).container
+    cat > $quadlet_file <<EOF
+[Container]
+ContainerName=$NAME
+Image=$IMAGE
+SecurityLabelType=spc_t
+SecurityLabelLevel=s0:c100,c200
+SecurityLabelFileType=container_ro_file_t
+Exec=sh -c "echo STARTED CONTAINER; echo "READY=1" | socat -u STDIN unix-sendto:\$NOTIFY_SOCKET; top"
+EOF
+
+    run_quadlet "$quadlet_file"
+    service_setup $QUADLET_SERVICE_NAME
+
+    # Ensure we have output. Output is synced via sd-notify (socat in Exec)
+    run journalctl "--since=$STARTED_TIME" --unit="$QUADLET_SERVICE_NAME"
+    is "$output" '.*STARTED CONTAINER.*'
+
+    run_podman container ps
+    run_podman container inspect  --format "{{.ProcessLabel}}" $NAME
+    is "$output" "system_u:system_r:spc_t:s0:c100,c200" "container should be started with correct Process Label"
+    run_podman container inspect  --format "{{.MountLabel}}" $NAME
+    is "$output" "system_u:object_r:container_ro_file_t:s0:c100,c200" "container should be started with correct Mount Label"
+
+    service_cleanup $QUADLET_SERVICE_NAME failed
+}
 
 # vim: filetype=sh